Deep brain stimulation — a novel surgical procedure — is emerging as a treatment of last resort for people diagnosed with neuropsychiatric disorders such as severe obsessive-compulsive disorder. The US Food and Drug Administration granted a so-called humanitarian device exemption to allow patients to access this intervention, thereby removing the requirement for a clinical trial of the appropriate size and statistical power. Bypassing the rigors of such trials puts patients at risk, limits opportunities for scientific discovery, and gives device manufacturers (...) unique marketing opportunities. We argue that Congress and federal regulators should revisit the humanitarian device exemption to ensure that it is not used to sidestep careful research that can offer valuable data with appropriate patient safeguards. (shrink)

Gilbert and colleagues point out the discrepancy between the limited empirical data illustrating changes in personality following implantation of deep brain stimulating electrodes and the vast number of conceptual neuroethics papers implying that these changes are widespread, deleterious, and clinically significant. Their findings are reminiscent of C. P. Snow’s essay on the divide between the two cultures of the humanities and the sciences. This division in the literature raises significant ethical concerns surrounding unjustified fear of personality changes in the context (...) of DBS and negative perceptions of clinician-scientists engaged in DBS. These concerns have real world implications for funding future innovative, DBS trials aimed to reduce suffering as well as hampering true interdisciplinary scholarship. We argue that the philosophical tradition of pragmatism and the value it places on empirical inquiry, experiential knowledge, and inter-disciplinary scholarship – reflecting diverse ways of knowing – provides a framework to start to address the important questions Gilbert and colleagues raise. In particular, we highlight the importance of expert clinician knowledge in contributing to the neuroethical questions raised by Gilbert and colleagues. Finally, we provide illustrative examples of some of our interdisciplinary empirical research that demonstrate the iterative cycle of inquiry characteristic of pragmatism in which conceptual neuroethics questions have led to empirical studies whose results then raise additional conceptual questions that give rise to new empirical studies in a way that highlights the contributions of the humanities and the sciences. (shrink)

The third volume of Ordo V in the Amsterdam edition of the Latin texts of Erasmus presents the second half of Erasmus’ commentaries on eleven Psalms. Two of them not only explain the psalms themselves, but also deal with topical questions, viz. the war against the Turks and the disintegration of Christendom.

Background: We aimed to determine the smallest changes in health-related quality of life (HRQoL) scores in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 and the Brain Cancer Module (QLQ-BN20), which could be considered as clinically meaningful in brain cancer patients. Materials and methods: World Health Organisation performance status (PS) and mini-mental state examination (MMSE) were used as clinical anchors appropriate to related subscales to determine the minimal clinically important differences (MCIDs) in HRQoL (...) change scores (range 0-100) in the QLQ-C30 and QLQ-BN20. A threshold of 0.2 standard deviation (SD) (small effect) was used to exclude anchor-based MCID estimates considered too small to inform interpretation. Results: Based on PS, our findings support the following integer estimates of the MCID for improvement and deterioration, respectively: physical (6, 9), role (14, 12), and cognitive functioning (8, 8); global health status (7, 4(star)), fatigue (12, 9), and motor dysfunction (4(star), 5). Anchoring with MMSE, cognitive functioning MCID estimates for improvement and deterioration were (11, 2(star)) and for communication deficit were (9, 7). Estimates with asterisks were <0.2 SD and were excluded from our MCID range of 5-14. Conclusion: These estimates can help clinicians evaluate changes in HRQoL over time, assess the value of a health care intervention and can be useful in determining sample sizes in designing future clinical trials. (shrink)

Relations between Turkish authorities and their Kurdish minority have been a source of conflict for decades. On 11 April 2015, in the run-up to Turkey’s parliamentary elections, a gunfight broke out in the south-eastern province of Ağrı, resulting in six Kurdish people being killed and four Turkish military personnel wounded. Although skirmishes like this are not unusual, this caught the public imagination as it became clear that Kurdish civilians had helped wounded Turkish soldiers after the shoot-out. The government denied such (...) help and was keen to place the blame for the fight on the Kurdish opposition in its attempt to dissuade the public from voting for Kurdish-oriented parties, thereby increasing their chances of securing a parliamentary majority. The Kurds were keen to do the same to the government for the sake of votes, while the mainstream opposition saw this as an opportunity to represent the government and Kurds as poor voting options. The Turkish media, polarised and closely aligned to political interests, recontextualised events in ways which showed their political ties. This article uses critical discourse analysis to show how this was done in three national newspapers. Furthermore, the article argues that representations as such do nothing to aid in solving the decades-old problem of how Turks and Kurds can coexist peacefully. (shrink)

Forty‐nine subjects judged the relevancy of sentence parts of a word problem (the Allsports problem). Patterns of subjects' judgments suggest three problem‐solving heuristics: a SETS heuristic, a TIME heuristic, and a QUESTION heuristic. Presentation of the question before the problem tends to suppress SETS and TIME heuristics. A computer program (ATTEND) is presented to simulate subjects' behavior on the Allsports problem. The program is context‐sensitive in that it can change a relevance judgment upon the acquisition of further information. Averaged subject (...) judgments and ATTEND judgments agree for 87% of the items. (shrink)

On the occasion of the 50th anniversary of C. S. Lewis’s death, a special annotated edition of his Christian classic, The Screwtape Letters, with notes and excerpts from his other works that help illuminate this diabolical masterpiece. Since its publication in 1942, The Screwtape Letters has sold millions of copies worldwide and is recognized as a milestone in the history of popular theology. A masterpiece of satire, it offers a sly and ironic portrayal of human life and foibles from the (...) vantage point of Screwtape, a highly placed assistant to “Our Father Below.” At once wildly comic, deadly serious, and strikingly original, The Screwtape Letters comprises the correspondence of the worldly-wise devil Screwtape and his nephew Wormwood, a novice demon in charge of securing the damnation of an ordinary young man. For the first time, The Screwtape Letters will be presented in full-text accompanied by helpful annotations in a striking two-color format. These annotations will give fans a deeper, more nuanced understanding of the popular book, providing background information, explanations of terms, historical significance, and excerpts from Lewis’s other works that more fully explain the ideas in this volume. For both expert Lewis fans and casual readers, The Screwtape Letters: Annotated Edition will be a beautiful and insightful guide to a beloved classic. (shrink)

I argue that mind-independence realism should be characterised in terms of what I call 'essential', rather than 'modal', independence from our mental lives. I explore the connections between the two kinds of independence, and argue that characterizations in terms of essence respect more intuitions about what realism is, harmonize better with standard characterizations of anti-realism, and avert the threat of subversion from Blackburn's quasi-realist.

"One basic and underlying assumption of this investigation will be that there is a distinct continuity and development in Berkeley's thought which can be traced through all of his reflective analyses of the problem of perception." The essay argues for Berkeley's theory of perception as a "prototype of the phenomenalists." It argues also for Berkeley's incorporation of elements from the representative theory of perception. Of special interest is the treatment of Berkeley's doctrine of "suggestion" and its connection with the role (...) of imagination in the perception of physical objects. The linguistic aspect of Berkeley's work is minimized. Berkeley's theory of notions receives only a passing reference. The last third of the book is a clear and useful discussion of Berkeley and contemporary phenomenalism. It is suggested, though not shown, that Berkeley has affinity with contemporary phenomenology of perception.--A. S. C. (shrink)

Are there dispositions which not only do not manifest, but which could not manifest? We argue that there are dispositions to Ф in circumstances C where C is impossible, and some where Ф is impossible. Furthermore, postulating these dispositions does useful theoretical work. This paper describes a number of cases of dispositions had by objects even though those dispositions are not possibly manifest, and argues for the importance of these dispositions.

Are a statue and the lump of clay that constitutes it one object or two? Many philosophers have answered ‘two’ because the lump seems to have properties, such as the property of being able to survive flattening, that the statue lacks. This answer faces a serious problem : it seems that nothing grounds the difference in properties between colocated objects. The statue and lump are in the same environment and inherit properties from the same composing parts. But it seems that (...) differences in properties should be grounded. For this reason, philosophers including Mark Heller, Dean Zimmerman, Theodore Sider, Trenton Merricks, and Eric Olson have rejected the answer ‘two’. -/- I offer a solution to the grounding problem, in order to revive the traditional account. I argue that extrinsic relations contribute to the supervenience base of many kinds or sorts, and these extrinsic relations ground differences between colocated objects, such as statues and lumps of clay, human beings and lumps of tissue, and planets and masses of matter. The same collection of parts can stand in more than one extrinsic relation, with each relation grounding the composition of a distinct kind of object. In cases in which this happens, the properties of each object differ from the properties of other objects that share the same parts. (shrink)

This is one of the seminal articles of the pragmatist tradition where C.S. Peirce sets out his doctrine of doubt and belief --and their relationship to inquiry and clarity of our concepts. Originally published in the Popular Science Monthly; and widely available in reprints and collections of Peirce's writings.

A repackaged edition of the revered author's classic work that examines the four types of human love: affection, friendship, erotic love, and the love of God—part of the C. S. Lewis Signature Classics series. C.S. Lewis—the great British writer, scholar, lay theologian, broadcaster, Christian apologist, and bestselling author of Mere Christianity, The Screwtape Letters, The Great Divorce, The Chronicles of Narnia, and many other beloved classics—contemplates the essence of love and how it works in our daily lives in one of (...) his most famous works of nonfiction. Lewis examines four varieties of human love: affection, the most basic form; friendship, the rarest and perhaps most insightful; Eros, passionate love; charity, the greatest and least selfish. Throughout this compassionate and reasoned study, he encourages readers to open themselves to all forms of love—the key to understanding that brings us closer to God. (shrink)

C. S. Lewis takes us on a profound journey through both heaven and hell in this engaging allegorical tale. Using his extraordinary descriptive powers, Lewis introduces us to supernatural beings who will change the way we think about good and evil.

This paper builds on some important recent work by Amie Thomasson, wherein she argues that recent disputes about the existence of ordinary objects have arisen due to eliminiativist metaphysicians’ misunderstandings. Some, she argues, are mistaken about how the language of quantification works, while others neglect the existence and significance of certain analytic entailments. Thomasson claims that once these misunderstandings are cleared away, it is trivially easy to answer existence questions about ordinary objects using everyday empirical methods of investigation. She reveals (...) how two conflicting metaontologies can lead to different positions in the first-order debate. In this paper, I bring a third metaontological perspective to the table: one that enables us to maintain that ontological disputes about ordinary objects are not trivially easy to settle, even if we agree with Thomasson that they are merely verbal. These are serious verbal disputes. (shrink)

Craig casts doubt upon the project of trying to give the traditional sort of necessary and sufficient conditions for A knows that p. He interprets the inadequacy of existing analyses of knowledge as evidence that our concept of knowledge is complex and diffuse, and concludes that we should aim to understand it by thinking about the rôle the concept plays in our lives, rather than by trying to find necessary and sufficient conditions for the truth of knowledge ascriptions.There is surely (...) something right about Craig's view: we are unlikely to succeed in any attempt to analyse away the intricacies in our concept of knowledge. We cannot realistically hope to uncover a set of necessary and sufficient conditions for A knows that p which are in all cases either clearly satisfied or clearly not satisfied. Nor, I suspect, is it possible to offer necessary and sufficient conditions for knowledge which are widely accepted as being more securely understood than knowledge itself. (shrink)

Under what circumstances if ever ought we to grant that Artificial Intelligences (AI) are persons? The question of whether AI could have the high degree of moral status that is attributed to human persons has received little attention. What little work there is employs western conceptions of personhood, while non-western approaches are neglected. In this article, I discuss African conceptions of personhood and their implications for the possibility of AI persons. I focus on an African account of personhood that is (...) prima facie inimical to the idea that AI could ever be ‘persons’ in the sense typically attributed to humans. I argue that despite its apparent anthropocentrism, this African account could admit AI as persons. (shrink)

We discuss explanation of an earlier event by a later event, and argue that prima facie cases of backwards event explanation are ubiquitous. Some examples: (1) I am tidying my flat because my brother is coming to visit tomorrow. (2) The scarlet pimpernels are closing because it is about to rain. (3) The volcano is smoking because it is going to erupt soon. We then look at various ways people might attempt to explain away these prima facie cases by arguing (...) that in each case the 'real' explanation is something else. We argue that none of the explaining-away strategies are successful, and so any plausible account of explanation should either make room for backwards explanation, or have a good story to tell about why it doesn't have to. (shrink)